First line drug treatment for hypertension and reductions in blood pressure according to age and ethnicity: cohort study in UK primary care.

ABSTRACT:

Objective

To study whether treatment recommendations based on age and ethnicity according to United Kingdom (UK) clinical guidelines for hypertension translate to blood pressure reductions in current routine clinical care.

Design

Observational cohort study.

Setting

UK primary care, from 1 January 2007 to 31 December 2017.

Participants

New users of angiotensin converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB), calcium channel blockers (CCB), and thiazides.

Main outcome measures

Change in systolic blood pressure in new users of ACEI/ARB versus CCB, stratified by age (< v ≥55) and ethnicity (black v non-black), from baseline to 12, 26, and 52 week follow-up. Secondary analyses included comparisons of new users of CCB with t

SUBMITTER: Sinnott SJ 

PROVIDER: S-EPMC7670766 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature