Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults.

ABSTRACT:

Background

Fine particulate matter (PM_2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies.

Methods

To measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, young volunteers to PM_2.5, in the form of concentrated ambient particles (mean: 37.8 μg/m³, SD 6.5), and filtered air (mean: 2.1 μg/m³, SD 2.6). In this double-blind, crossover study the exposure order was randomized. During the 4 h exposure, volunteers (7 females and 13 males) underwent light intensity exercise to regulate ventilation rate. We measured pulmonary, cardiac, and hematologic end points before exposure, 1 

SUBMITTER: Wyatt LH 

PROVIDER: S-EPMC7670817 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature