Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody.

ABSTRACT: CXCR1 and CXCR2 signaling play a critical role in neutrophil migration, angiogenesis, and tumorigenesis and are therefore an attractive signaling axis to target in a variety of indications. In human, a total of seven chemokines signal through these receptors and comprise the ELR⁺CXC chemokine family, so named because of the conserved ELRCXC N-terminal motif. To fully antagonize CXCR1 and CXCR2 signaling, an effective therapeutic should block either both receptors or all seven ligands, yet neither approach has been fully realized clinically. In this work, we describe the generation and characterization of LY3041658, a humanized monoclonal antibody that binds and neutralizes all seven human and cynomolgus monkey ELR⁺CXC chemokines and three of five mouse and rat ELR

SUBMITTER: Boyles JS 

PROVIDER: S-EPMC7671035 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature