Tumor-infiltrating podoplanin⁺ cells in gastric cancer: clinical outcomes and association with immune contexture.

ABSTRACT: Podoplanin (PDPN) has been proved to have significant immunoregulatory effects in several types of malignancies and is considered to be a novel immune checkpoint molecule. However, the clinical significance of PDPN and its potential influence on immune contexture in gastric cancer remain obscure. Here, we aimed to investigate the clinical outcomes and immunoregulatory role of tumor-infiltrating PDPN⁺ cells (tPDPNs) in gastric cancer. A total of 454 tumor tissue microarray specimens and 68 fresh tumor tissues of gastric cancer patients from Zhongshan Hospital, and transcriptional data of 293 gastric cancer patients from The Cancer Genome Atlas were included. We demonstrated that tPDPNs high subgroup experienced worse overall survival and disease-free survival, and indicated infer

SUBMITTER: Liu X 

PROVIDER: S-EPMC7671044 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature