Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma.
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ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC7671052 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma.
Zhou Weihua W Wahl Daniel R DR
Molecular & cellular oncology 20201027 6
Profound intratumoral genomic heterogeneity has limited the ability of targeted therapies to overcome therapy resistance in glioblastoma. We have defined purine metabolism as a key mediator of DNA repair and radiation resistance in glioblastoma. Because many glioblastoma oncogenic drivers activate purine metabolism, its inhibition may overcome therapy resistance despite intratumoral genomic heterogeneity. ...[more]
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