Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma.

ABSTRACT: Profound intratumoral genomic heterogeneity has limited the ability of targeted therapies to overcome therapy resistance in glioblastoma. We have defined purine metabolism as a key mediator of DNA repair and radiation resistance in glioblastoma. Because many glioblastoma oncogenic drivers activate purine metabolism, its inhibition may overcome therapy resistance despite intratumoral genomic heterogeneity.

SUBMITTER: Zhou W 

PROVIDER: S-EPMC7671052 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature