Sequence variation, common tissue expression patterns and learning models: a genome-wide survey of vertebrate ribosomal proteins.

ABSTRACT: Ribosomal genes produce the constituents of the ribosome, one of the most conserved subcellular structures of all cells, from bacteria to eukaryotes, including animals. There are notions that some protein-coding ribosomal genes vary in their roles across species, particularly vertebrates, through the involvement of some in a number of genetic diseases. Based on extensive sequence comparisons and systematic curation, we establish a reference set for ribosomal proteins (RPs) in eleven vertebrate species and quantify their sequence conservation levels. Moreover, we correlate their coordinated gene expression patterns within up to 33 tissues and assess the exceptional role of paralogs in tissue specificity. Importantly, our analysis supported by the development and use of machine learning mode

SUBMITTER: Kyritsis KA 

PROVIDER: S-EPMC7671327 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature