AliFreeFoldMulti: alignment-free method to predict secondary structures of multiple RNA homologs.

ABSTRACT: Predicting RNA structure is crucial for understanding RNA's mechanism of action. Comparative approaches for the prediction of RNA structures can be classified into four main strategies. The three first-align-and-fold, align-then-fold and fold-then-align-exploit multiple sequence alignments to improve the accuracy of conserved RNA-structure prediction. Align-and-fold methods perform generally better, but are also typically slower than the other alignment-based methods. The fourth strategy-alignment-free-consists in predicting the conserved RNA structure without relying on sequence alignment. This strategy has the advantage of being the faster, while predicting accurate structures through the use of latent representations of the candidate structures for each sequence. This paper presents ali

SUBMITTER: Bossanyi MA 

PROVIDER: S-EPMC7671329 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature