The cis-regulatory codes of response to combined heat and drought stress in Arabidopsis thaliana.

ABSTRACT: Plants respond to their environment by dynamically modulating gene expression. A powerful approach for understanding how these responses are regulated is to integrate information about cis-regulatory elements (CREs) into models called cis-regulatory codes. Transcriptional response to combined stress is typically not the sum of the responses to the individual stresses. However, cis-regulatory codes underlying combined stress response have not been established. Here we modeled transcriptional response to single and combined heat and drought stress in Arabidopsis thaliana. We grouped genes by their pattern of response (independent, antagonistic and synergistic) and trained machine learning models to predict their response using putative CREs (pCREs) as features (me

SUBMITTER: Azodi CB 

PROVIDER: S-EPMC7671360 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature