Efficient, quick and easy-to-use DNA replication timing analysis with START-R suite.

ABSTRACT: DNA replication must be faithful and follow a well-defined spatiotemporal program closely linked to transcriptional activity, epigenomic marks, intranuclear structures, mutation rate and cell fate determination. Among the readouts of the spatiotemporal program of DNA replication, replication timing analyses require not only complex and time-consuming experimental procedures, but also skills in bioinformatics. We developed a dedicated Shiny interactive web application, the START-R (Simple Tool for the Analysis of the Replication Timing based on R) suite, which analyzes DNA replication timing in a given organism with high-throughput data. It reduces the time required for generating and analyzing simultaneously data from several samples. It automatically detects different types of timing regi

SUBMITTER: Hadjadj D 

PROVIDER: S-EPMC7671386 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature