DeepMicrobes: taxonomic classification for metagenomics with deep learning.

ABSTRACT: Large-scale metagenomic assemblies have uncovered thousands of new species greatly expanding the known diversity of microbiomes in specific habitats. To investigate the roles of these uncultured species in human health or the environment, researchers need to incorporate their genome assemblies into a reference database for taxonomic classification. However, this procedure is hindered by the lack of a well-curated taxonomic tree for newly discovered species, which is required by current metagenomics tools. Here we report DeepMicrobes, a deep learning-based computational framework for taxonomic classification that allows researchers to bypass this limitation. We show the advantage of DeepMicrobes over state-of-the-art tools in species and genus identification and comparable accuracy in abund

SUBMITTER: Liang Q 

PROVIDER: S-EPMC7671387 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature