Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas.

ABSTRACT: Esophageal atresia (EA) and tracheoesophageal fistula (TEF) are relatively frequently occurring foregut malformations. EA/TEF is thought to have a strong genetic component. Not much is known regarding the biological processes disturbed or which cell type is affected in patients. This hampers the detection of the responsible culprits (genetic or environmental) for the origin of these congenital anatomical malformations. Therefore, we examined gene expression patterns in the TEF and compared them to the patterns in esophageal, tracheal and lung control samples. We studied tissue organization and key proteins using immunohistochemistry. There were clear differences between TEF and control samples. Based on the number of differentially expressed genes as well as histological characteristics, T

SUBMITTER: Brosens E 

PROVIDER: S-EPMC7671559 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature