CsrA Supports both Environmental Persistence and Host-Associated Growth of Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is an opportunistic and frequently multidrug-resistant Gram-negative bacterial pathogen that primarily infects critically ill individuals. Indirect transmission from patient to patient in hospitals can drive infections, supported by this organism's abilities to persist on dry surfaces and rapidly colonize susceptible individuals. To investigate how A. baumannii survives on surfaces, we cultured A. baumannii in liquid media for several days and then analyzed isolates that lost the ability to survive drying. One of these isolates carried a mutation that affected the gene encoding the carbon storage regulator CsrA. As we began to examine the role of CsrA in A. baumannii, we observed that the growth of ΔcsrA mutant strains was inhibited in the presence of amino acids. T

SUBMITTER: Farrow JM 

PROVIDER: S-EPMC7671896 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature