Genome-wide identification of imprinted genes in pigs and their different imprinting status compared with other mammals.

ABSTRACT: Genomic imprinting often results in parent-of-origin specific differential expression of maternally and paternally inherited alleles and plays an essential role in mammalian development and growth. Mammalian genomic imprinting has primarily been studied in mice and humans, with only limited information available for pigs. To systematically characterize this phenomenon and evaluate imprinting status between different species, we investigated imprinted genes on a genome-wide scale in pig brain tissues. Specifically, we performed bioinformatics analysis of high-throughput sequencing results from parental genomes and offspring transcriptomes of hybrid crosses between Duroc and Diannan small-ear pigs. We identified 11 paternally and five maternally expressed imprinted genes in pigs with highly

SUBMITTER: Wu YQ 

PROVIDER: S-EPMC7671905 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature