Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.

ABSTRACT: Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death^1-4. Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hamsters^5-7 and nonhuman primates^8-10 have generally reported mild clinical disease, and preclinical SARS-CoV-2 vaccine studies have demonstrated reduction of viral replication in the upper and lower respiratory tracts in nonhuman primates^11-13. Here we show that high-dose intranasal SARS-CoV-2 infection in hamsters results in severe clinical disease, including high levels of virus replication in tissues, extensive pneumonia, weight loss and mortality in a subset of animals. A single immunization with a

SUBMITTER: Tostanoski LH 

PROVIDER: S-EPMC7671939 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature