The effect of bile acids on the growth and global gene expression profiles in Akkermansia muciniphila.

ABSTRACT: Akkermansia muciniphila is a prominent member of the gut microbiota and the organism gets exposed to bile acids within this niche. Several gut bacteria have bile response genes to metabolize bile acids or an ability to change their membrane structure to prevent membrane damage from bile acids. To understand the response to bile acids and how A. muciniphila can persist in the gut, we studied the effect of bile acids and individual bile salts on growth. In addition, the change in gene expression under ox-bile condition was studied. The growth of A. muciniphila was inhibited by ox-bile and the bile salts mixture. Individual bile salts have differential effects on the growth. Although most bile salts inhibited the growth of A. muciniphila, an increased growth was observed under culture conditi

SUBMITTER: Hagi T 

PROVIDER: S-EPMC7671984 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature