PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation.

ABSTRACT: Transcriptional control of hematopoiesis involves complex regulatory networks and functional perturbations in one of these components often results in malignancies. Loss-of-function mutations in PHF6, encoding a presumed epigenetic regulator, have been primarily described in T cell acute lymphoblastic leukemia (T-ALL) and the first insights into its function in normal hematopoiesis only recently emerged from mouse modeling experiments. Here, we investigated the role of PHF6 in human blood cell development by performing knockdown studies in cord blood and thymus-derived hematopoietic precursors to evaluate the impact on lineage differentiation in well-established in vitro models. Our findings reveal that PHF6 levels differentially impact the differentiation of human hem

SUBMITTER: Loontiens S 

PROVIDER: S-EPMC7672048 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature