Operant conditioning of motor cortex neurons reveals neuron-subtype-specific responses in a brain-machine interface task.

ABSTRACT: Operant conditioning is implemented in brain-machine interfaces (BMI) to induce rapid volitional modulation of single neuron activity to control arbitrary mappings with an external actuator. However, intrinsic factors of the volitional controller (i.e. the brain) or the output stage (i.e. individual neurons) might hinder performance of BMIs with more complex mappings between hundreds of neurons and actuators with multiple degrees of freedom. Improved performance might be achieved by studying these intrinsic factors in the context of BMI control. In this study, we investigated how neuron subtypes respond and adapt to a given BMI task. We conditioned single cortical neurons in a BMI task. Recorded neurons were classified into bursting and non-bursting subtypes based on their spike-train auto

SUBMITTER: Garcia-Garcia MG 

PROVIDER: S-EPMC7672061 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature