Identification of synthetic chemosensitivity genes paired with BRAF for BRAF/MAPK inhibitors.

ABSTRACT: Molecular-targeted approaches are important for personalised cancer treatment, which requires knowledge regarding drug target specificity. Here, we used the synthetic lethality concept to identify candidate gene pairs with synergistic effects on drug responses. A synergistic chemo-sensitivity response was identified if a drug had a significantly lower half-maximal inhibitory concentration (IC₅₀) in cell lines with a pair of mutated genes compared with those in other cell lines (wild-type or one mutated gene). Among significantly damaging mutations in the Genomics of Drug Sensitivity in Cancer database, we found 580 candidate synergistic chemo-sensitivity interaction sets for 456 genes and 54 commercial drugs. Clustering analyses according to drug/gene and drug/tissue interaction

SUBMITTER: Lee KH 

PROVIDER: S-EPMC7672081 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature