Multiplexed quantitative proteomics provides mechanistic cues for malaria severity and complexity.

ABSTRACT: Management of severe malaria remains a critical global challenge. In this study, using a multiplexed quantitative proteomics pipeline we systematically investigated the plasma proteome alterations in non-severe and severe malaria patients. We identified a few parasite proteins in severe malaria patients, which could be promising from a diagnostic perspective. Further, from host proteome analysis we observed substantial modulations in many crucial physiological pathways, including lipid metabolism, cytokine signaling, complement, and coagulation cascades in severe malaria. We propose that severe manifestations of malaria are possibly underpinned by modulations of the host physiology and defense machinery, which is evidently reflected in the plasma proteome alterations. Importantly, we ident

SUBMITTER: Kumar V 

PROVIDER: S-EPMC7672109 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature