Association Between Demodex Infestation and Ocular Surface Microbiota in Patients With Demodex Blepharitis.

ABSTRACT: Purpose: The aim of this study was to compare the ocular microbial communities in humans with and without demodex blepharitis in order to elucidate the relationship between ocular microorganisms and demodex infestation. Methods: Bacterial 16S rRNA genes of conjunctival sac samples from 30 demodex blepharitis patients and 14 healthy controls were sequenced using a pyrosequencing method, and their bacterial community structures were compared by bioinformatics. Results: Bacterial community clustering of conjunctival sac in the demodex blepharitis group were significantly distinct from the healthy control group, with significantly higher relative abundances of Firmicutes and Corynebacterium at the phyla level, as well as higher abundances of Lactobacillus and

SUBMITTER: Yan Y 

PROVIDER: S-EPMC7672197 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature