A Network Pharmacology Approach to Investigate the Anticancer Mechanism and Potential Active Ingredients of Rheum palmatum L. Against Lung Cancer via Induction of Apoptosis.

ABSTRACT: Rheum palmatum L. (RPL) is a known traditional herbal medicine with the functions of "heat-clearing and damp-drying" in traditional Chinese medicine. Its anti-cancer effect against lung cancer has been confirmed previously, but the related mechanisms and active substances for its action has been little studied. This study adopted the network pharmacology, built the network map of drug ingredients and disease targets (DDN), and discussed the effective components of RPL and its possible mechanisms. All constituents of RPL were collected through database search and literature mining, and the potential active constituents were screened. The inverse pharmacophore matching model was used to predict the targets of active ingredients, and the method was supplemented by database retri

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7672213 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature