Neuronal processes and glial precursors form a scaffold for wiring the developing mouse cochlea.

ABSTRACT: In the developing nervous system, axons navigate through complex terrains that change depending on when and where outgrowth begins. For instance, in the developing cochlea, spiral ganglion neurons extend their peripheral processes through a growing and heterogeneous environment en route to their final targets, the hair cells. Although the basic principles of axon guidance are well established, it remains unclear how axons adjust strategies over time and space. Here, we show that neurons with different positions in the spiral ganglion employ different guidance mechanisms, with evidence for both glia-guided growth and fasciculation along a neuronal scaffold. Processes from neurons in the rear of the ganglion are more directed and grow faster than those from neurons at the border of the gangl

SUBMITTER: Druckenbrod NR 

PROVIDER: S-EPMC7672226 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature