Determinants of correlated expression of transcription factors and their target genes.

ABSTRACT: While transcription factors (TFs) are known to regulate the expression of their target genes (TGs), only a weak correlation of expression between TFs and their TGs has generally been observed. As lack of correlation could be caused by additional layers of regulation, the overall correlation distribution may hide the presence of a subset of regulatory TF-TG pairs with tight expression coupling. Using reported regulatory pairs in the plant Arabidopsis thaliana along with comprehensive gene expression information and testing a wide array of molecular features, we aimed to discern the molecular determinants of high expression correlation of TFs and their TGs. TF-family assignment, stress-response process involvement, short genomic distances of the TF-binding sites to the transcription start si

SUBMITTER: Zaborowski AB 

PROVIDER: S-EPMC7672440 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature