Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis.

ABSTRACT:

Background

Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD). The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise evidence on the association of platelet activation in HIV-infected patients on successful treatment.

Methods

Electronic databases were searched from inception until November 2019. Studies were included if the primary or secondary outcome of the study was to assess platelet activation in HIV-infected patients on ART. The primary outcome of this review included the levels of platelet activation. The pooled effect estimates were calculated using a random-effects met

SUBMITTER: Nkambule BB 

PROVIDER: S-EPMC7672943 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature