Immune landscape of periodontitis unveils alterations of infiltrating immunocytes and molecular networks-aggregating into an interactive web-tool for periodontitis related immune analysis and visualization.

ABSTRACT:

Background

Immunity reaction plays an essential role in periodontitis progress and we aim to investigate the underlying regulatory network of immune reactions in periodontitis.

Methods

CIBERSORT was used to estimate immunocyte fractions in different clinical statuses. Logistic regression was used to assess the immunocyte weight in periodontitis. Immune-related periodontitis subtypes were identified by the Nonnegative Matrix Factorization algorithm. Gene-set enrichment analysis and Gene-set variation analysis were conducted to analyze pathway activities. Immunocytes related gene modules were identified by Weighted gene co-expression network analysis.

Results

Altered immunocytes in healthy versus periodontitis, aggressive versus chronic, male versus female and age were

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7672958 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature