MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus.

ABSTRACT: Long-term memory formation is supported by functional and structural changes of neuronal networks, which rely on de novo gene transcription and protein synthesis. The modulation of the neuronal transcriptome in response to learning depends on transcriptional and post-transcriptional mechanisms. DNA methylation writers and readers regulate the activity-dependent genomic program required for memory consolidation. The most abundant DNA methylation reader, the Methyl CpG binding domain protein 2 (MeCP2), has been shown to regulate alternative splicing, but whether it establishes splicing events important for memory consolidation has not been investigated. In this study, we identified the alternative splicing profile of the mouse hippocampus in basal conditions and after a spatial learning expe

SUBMITTER: Brito DVC 

PROVIDER: S-EPMC7672966 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature