A computational diffusion model to study antibody transport within reconstructed tumor microenvironments.

ABSTRACT:

Background

Antibodies revolutionized cancer treatment over the past decades. Despite their successfully application, there are still challenges to overcome to improve efficacy, such as the heterogeneous distribution of antibodies within tumors. Tumor microenvironment features, such as the distribution of tumor and other cell types and the composition of the extracellular matrix may work together to hinder antibodies from reaching the target tumor cells. To understand these interactions, we propose a framework combining in vitro and in silico models. We took advantage of in vitro cancer models previously developed by our group, consisting of tumor cells and fibroblasts co-cultured in 3D within alginate capsules, for reconstruction of tumor microenvironment features.

Results

I

SUBMITTER: Cartaxo AL 

PROVIDER: S-EPMC7672975 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature