Specific decreasing of Na⁺ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome.

ABSTRACT: Reduced cardiac sodium (Na⁺) channel current (I_Na) resulting from the loss-of-function of Na⁺ channel is a major cause of lethal arrhythmias in Brugada syndrome (BrS). Inspired by previous experimental studies which showed that in heart diseases I_Na was reduced along with expression changes in Na⁺ channel within myocytes, we hypothesized that the local decrease in I_Na caused by the alteration in Na⁺ channel expression in myocytes leads to the occurrence of phase-2 reentry, the major triggering mechanism of lethal arrhythmias in BrS. We constructed in silico human ventricular myocardial strand and ring models, and examined whether the Na⁺ channel expression changes in each myocyte cause the phase-2 reent

SUBMITTER: Tsumoto K 

PROVIDER: S-EPMC7673036 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature