Follistatin expressed in mechanically-damaged salivary glands of male mice induces proliferation of CD49f⁺ cells.

ABSTRACT: Salivary glands (SGs) are very important for maintaining the physiological functions of the mouth. When SGs regenerate and repair from various damages, including mechanical, radiological, and immune diseases, acinar and granular duct cells originate from intercalated duct cells. However, the recovery is often insufficient because of SGs' limited self-repair function. Furthermore, the precise repair mechanism has been unclear. Here, we focused on CD49f, one of the putative stem cell markers, and characterized CD49f positive cells (CD49f⁺ cells) isolated from male murine SGs. CD49f⁺ cells possess self-renewal ability and express epithelial and pluripotent markers. Compared to CD49f negative cells, freshly isolated CD49f⁺ cells highly expressed inhibin beta A

SUBMITTER: Ikeda A 

PROVIDER: S-EPMC7673039 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature