Beagle dog 90-day oral toxicity study of a novel coccidiostat - ethanamizuril.

ABSTRACT:

Background

Triazine coccidiostats are widely used in chickens and turkeys for coccidiosis control. Ethanamizuril is a novel triazine compound that exhibits anticoccidial activity in poultry. This study was designed to evaluate the subchronic toxicity of ethanamizuril in beagle dogs at doses of 12, 60 or 300 mg/kg/day in diet for 90 days.

Results

Ethanamizuril was well tolerated at low and middle dosages in beagle dogs, and no drug-related toxical effects were observaed in terms of survival, clinical observations, organs weight and damage in these dose groups. However, in high dose administration group, food consumption and histologic changes in kidneys were noticed in both sexes of beagle dog, although the renal lesions were finally resolved at the end of 4 weeks exposure of

SUBMITTER: Zhang K 

PROVIDER: S-EPMC7673092 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature