Minimally invasive system to reliably characterize ventricular electrophysiology from living donors.

ABSTRACT: Cardiac tissue slices preserve the heterogeneous structure and multicellularity of the myocardium and allow its functional characterization. However, access to human ventricular samples is scarce. We aim to demonstrate that slices from small transmural core biopsies collected from living donors during routine cardiac surgery preserve structural and functional properties of larger myocardial specimens, allowing accurate electrophysiological characterization. In pigs, we compared left ventricular transmural core biopsies with transmural tissue blocks from the same ventricular region. In humans, we analyzed transmural biopsies and papillary muscles from living donors. All tissues were vibratome-sliced. By histological analysis of the transmural biopsies, we showed that tissue architecture and

SUBMITTER: Olivan-Viguera A 

PROVIDER: S-EPMC7673124 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature