Depot Medroxyprogesterone Acetate Use and Blood Lead Levels in a Cohort of Young Women.

ABSTRACT:

Background

Injectable contraceptive use is common, with 74 million users worldwide. Use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) is associated with bone mineral density loss. We hypothesize that increased bone resorption with DMPA use allows for mobilization of the toxic metal lead stored in bone to blood, presenting users with increased systemic exposure to lead.

Objective

The objective of our study was to investigate the association between current DMPA use and blood lead concentrations.

Methods

We conducted a cross-sectional analysis using enrollment data from the Study of Environment, Lifestyle & Fibroids (SELF), a cohort of 1,693 African-American women who were 23-35 years of age. Data on DMPA use were collected by computer-assiste

SUBMITTER: Upson K 

PROVIDER: S-EPMC7673223 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature