Comparison of chemotherapy effects on mechanical sensitivity and food-maintained operant responding in male and female rats.

ABSTRACT: Chemotherapies of varying classes often cause neuropathy and debilitating chemotherapy-induced neuropathic pain sufficient to limit treatment and reduce quality of life for many patients battling cancer. There are currently no effective preventive or alleviative treatments for chemotherapy-induced neuropathic pain. Preclinical models have been developed to test candidate chemotherapy-induced neuropathic pain treatments; however, studies using these models rarely provide direct comparisons of effects of different chemotherapies or assess the degree to which chemotherapies produce clinically relevant signs of pain-depressed behavior. Male and female Sprague-Dawley rats received four injections of vehicle, paclitaxel, oxaliplatin, vincristine, or bortezomib on alternate days. Mechanical hyper

SUBMITTER: Legakis LP 

PROVIDER: S-EPMC7673225 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature