Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.

ABSTRACT:

Background

Acetaminophen (APAP) overdose is one of the major etiologies of liver failure. Hepatocyte necrosis induced by toxic metabolites of APAP can activate proinflammatory responses, including elastase-expressing neutrophils, to exacerbate liver injury. Myeloid-derived suppressor cells (MDSCs) increased in inflammation can inhibit proinflammatory responses. Our aim is to investigate the role of MDSC in APAP-induced liver failure and the possible therapeutic application.

Methods

BLAB/c mice were injected with a sublethal/lethal dose of APAP as the murine model of liver failure. MDSCs were defined as CD11b⁺Gr-1⁺ cells with the ability of T-cell suppression.

Results

A sublethal challenge of APAP could increase the intrahepatic MDSC and protect m

SUBMITTER: Hsu CY 

PROVIDER: S-EPMC7673381 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature