Brain Network Segregation and Glucose Energy Utilization: Relevance for Age-Related Differences in Cognitive Function.

ABSTRACT: The human brain is organized into segregated networks with strong within-network connections and relatively weaker between-network connections. This "small-world" organization may be essential for maintaining an energetically efficient system, crucial to the brain which consumes 20% of the body's energy. Brain network segregation and glucose energy utilization both change throughout the lifespan. However, it remains unclear whether these processes interact to contribute to differences in cognitive performance with age. To address this, we examined fluorodeoxyglucose-positron emission tomography and resting-state functional magnetic resonance imaging from 88 participants aged 18-73 years old. Consistent with prior work, brain network segregation showed a negative association with age across

SUBMITTER: Manza P 

PROVIDER: S-EPMC7673478 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature