Brain Wiring and Supragranular-Enriched Genes Linked to Protracted Human Frontal Cortex Development.

ABSTRACT: The human frontal cortex is unusually large compared with many other species. The expansion of the human frontal cortex is accompanied by both connectivity and transcriptional changes. Yet, the developmental origins generating variation in frontal cortex circuitry across species remain unresolved. Nineteen genes that encode filaments, synapse, and voltage-gated channels are especially enriched in the supragranular layers of the human cerebral cortex, which suggests enhanced corticocortical projections emerging from layer III. We identify species differences in connections with the use of diffusion MR tractography as well as gene expression in adulthood and in development to identify developmental mechanisms generating variation in frontal cortical circuitry. We demonstrate that increased e

SUBMITTER: Hendy JP 

PROVIDER: S-EPMC7673480 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature