Progressive Cactus is a multiple-genome aligner for the thousand-genome era.

ABSTRACT: New genome assemblies have been arriving at a rapidly increasing pace, thanks to decreases in sequencing costs and improvements in third-generation sequencing technologies^1-3. For example, the number of vertebrate genome assemblies currently in the NCBI (National Center for Biotechnology Information) database⁴ increased by more than 50% to 1,485 assemblies in the year from July 2018 to July 2019. In addition to this influx of assemblies from different species, new human de novo assemblies⁵ are being produced, which enable the analysis of not only small polymorphisms, but also complex, large-scale structural differences between human individuals and haplotypes. This coming era and its unprecedented amount of data offer the opportunity to uncover many insight

SUBMITTER: Armstrong J 

PROVIDER: S-EPMC7673649 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature