Quantification of Renal Sympathetic Vasomotion as a Novel End Point for Renal Denervation.

ABSTRACT: Renal sympathetic denervation, a potentially revolutionary interventional treatment for hypertension, faces an existential problem due to the inability to confirm successful ablation of the targeted renal sympathetic nerves. Based on the observation that renal sympathetic nerve activity exerts rhythmic, baroreflex-driven, and vasoconstrictive control of the renal vasculature, we developed a novel technique for identifying rhythmic sympathetic vascular control using a time-varying, 2-component Windkessel model of the renal circulation. This technology was tested in 2 different animal models of renal denervation; 10 rabbits underwent chronic, surgical renal denervation, and 9 pigs underwent acute, functional renal denervation via intrathecal administration of ropivacaine. Both methods of ren

SUBMITTER: Pellegrino PR 

PROVIDER: S-EPMC7673653 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature