CD8⁺ T cells mediate protection against Zika virus induced by an NS3-based vaccine.

ABSTRACT: Zika virus (ZIKV) is associated with congenital malformations in infants born to infected mothers, and with Guillain-Barré syndrome in infected adults. Development of ZIKV vaccines has focused predominantly on the induction of neutralizing antibodies, although a suboptimal antibody response may theoretically enhance disease severity through antibody-dependent enhancement (ADE). Here, we report induction of a protective anti-ZIKV CD8⁺ T cell response in the HLA-B*0702 Ifnar1^-/- transgenic mice using an alphavirus-based replicon RNA vaccine expressing ZIKV nonstructural protein NS3, a potent T cell antigen. The NS3 vaccine did not induce a neutralizing antibody response but elicited polyfunctional CD8⁺ T cells that were necessary and sufficient for pre

SUBMITTER: Elong Ngono A 

PROVIDER: S-EPMC7673678 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature