Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population.

ABSTRACT:

Purpose

Multiple sclerosis (MS) is an autoimmune disease, and genetic factors play an important role in its pathogenesis and progression. The aim of our study was to evaluate the frequencies of alleles and genetic variants of the T-cell homeostasis-related genes, in subjects with MS, as well as to investigate the association with MS clinical manifestations and disability.

Methods

94 subjects with MS and 160 healthy individuals have been genotyped for seven common single-nucleotide variants in IL-2RA, CTLA4, CD40, and PADI4 genes. The ages of onset, duration of the disease, and clinical condition of the MS subjects were analysed. We used the Chi² test confirmed with Fisher's exact test for statistical analysis.

Results

The frequency of allele T and CT/TT gen

SUBMITTER: Chorazy M 

PROVIDER: S-EPMC7673932 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature