Dataset Information
The Class A Carbapenemases BKC-1 and GPC-1 Both Originate from the Bacterial Genus Shinella.
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ABSTRACT:
SUBMITTER: Kieffer N
PROVIDER: S-EPMC7674036 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
The Class A Carbapenemases BKC-1 and GPC-1 Both Originate from the Bacterial Genus <i>Shinella</i>.
Antimicrobial agents and chemotherapy 20201117 12
Comparative genomics identified the environmental bacterial genus <i>Shinella</i> as the most likely origin of the class A carbapenemases BKC-1 and GPC-1. Available sequences and PCR analyses of additional <i>Shinella</i> species revealed homologous β-lactamases showing up to 85.4% and 93.3% amino acid identity to both enzymes, respectively. The genes conferred resistance to β-lactams once expressed in <i>Escherichia coli</i><i>bla</i><sub>BKC-1</sub> likely evolved from a putative ancestral <i> ...[more]