Outcomes in Participants with Renal Impairment from a Phase 3 Clinical Trial for Ceftolozane/Tazobactam Treatment of Nosocomial Pneumonia (ASPECT-NP).

ABSTRACT: In the phase 3 ASPECT-NP trial (NCT02070757), ceftolozane/tazobactam (C/T) was noninferior to meropenem for treatment of Gram-negative ventilated hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (vHABP/VABP). Here, we report outcomes in participants from ASPECT-NP with renal impairment (RI). Participants were categorized by their baseline renal function as follows: normal renal function (NRF; creatinine clearance [CL_CR], ≥80 ml/min), mild RI (CL_CR, >50 to <80 ml/min), moderate RI (CL_CR, ≥30 to ≤50 ml/min), and severe RI (CL_CR, ≥15 to <30 ml/min). Dosing of both study drugs was adjusted based on renal function. The following C/T doses were administered every 8 h: NRF or mild RI, 3 g; moderate RI, 1.5 g; and sever

SUBMITTER: Huntington JA 

PROVIDER: S-EPMC7674039 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature