Matched Case-Control Study of the Long-Term Impact of Beta-Lactam Antibiotic Allergy Testing.
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ABSTRACT:
SUBMITTER: Trubiano JA
PROVIDER: S-EPMC7674060 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Matched Case-Control Study of the Long-Term Impact of Beta-Lactam Antibiotic Allergy Testing.
Trubiano Jason A JA Marhoon Nada N Vogrin Sara S Chua Kyra Y L KYL Holmes Natasha E NE
Antimicrobial agents and chemotherapy 20201117 12
Whereas the short-term impacts of antibiotic allergy testing on delabeling and antibiotic usage have been demonstrated, the long-term impacts have been less well defined. In a single-center matched case-control study from Melbourne, Australia, we demonstrate that a beta-lactam antibiotic allergy testing program has a significant impact on antibiotic usage and infection-related outcomes. This study supports implementation of an antibiotic allergy testing program as a standard of care of antimicro ...[more]
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Project description:In a cross-sectional study of 20 Massachusetts long-term care (LTC) facilities, 19% (n = 449) of residents received antibiotics, with approximately one-third having a documented penicillin allergy. This documented allergy decreased the likelihood of prescribing beta-lactam antibiotics for infections. Improved penicillin allergy assessments and delabeling could optimize antibiotic prescribing in LTC settings.
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