Analysis of the interaction effect of 48 SNPs and obesity on type 2 diabetes in Chinese Hans.

ABSTRACT:

Introduction

Both environmental and genetic factors contribute to type 2 diabetes (T2D) risk. Dozens of T2D susceptibility loci have been identified by genome-wide association study. However, these loci account for only a small fraction of the familial T2D risk. We hypothesized that the gene-obesity interaction may contribute to the missing heritability.

Research design and method

Forty-eight T2D-associated variants were genotyped using the TaqMan OpenArray Genotyping System and iPLEX Sequenom MassARRAY platform in two separate studies. Obesity was defined according to multiple indexes (body mass index (BMI), waist circumference and waist-hip ratio). Multiplicative interactions were tested using general logistic regression to assess the gene-obesity interaction effect on T2D

SUBMITTER: Liu J 

PROVIDER: S-EPMC7674088 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature