Treatment of hypertension reduces cognitive decline in older adults: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To systematically analyse the effect of pharmacological treatment of hypertension (HTN) on cognitive decline in older adults.

Methods

Randomised, placebo-controlled trials with a prespecified quantitative outcome of cognition and a pharmacological intervention for at least 12 months to treat HTN in older adults (>60 years). Our primary outcome was change in cognition with pharmacological treatment of HTN. Standardised mean difference (SMD) was used to analyse different outcomes reported in the selected studies. We searched PubMed CENTRAL and the Cochrane Library from inception to 6 July 2020. Two independent reviewers assessed trial quality and extracted data. Internal and external validity of the studies was assessed.

Results

Nine randomised controlled tri

SUBMITTER: Gupta A 

PROVIDER: S-EPMC7674095 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature