Glutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset.

ABSTRACT:

Introduction

Type 2 diabetes (T2D) is a multifactorial disease affecting mostly adults older than 40 years. The aim of the study was to examine GST gene polymorphism influence on the risk of T2D, especially in young adults.

Research design and methods

200 diabetic patients and 221 healthy controls participated in this study. Three GST gene polymorphism have been analyzed: GSTP1 (single-nucleotide polymorphism Ile₁₀₅Val), homozygous deletion of GSTT1 (null/null) and GSTM1 (null/null), using TaqMan real-time quantitative PCR.

Results

The distribution of examined polymorphisms was similar in patient group and control group. Statistically significant differences were demonstrated for the combination of GSTP1 Val/Val and

SUBMITTER: Klusek J 

PROVIDER: S-EPMC7674104 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature