Estimating the Impact of Verification Bias on Celiac Disease Testing.

ABSTRACT:

Goal

The goal of this study was to estimate the impact of verification bias on the diagnostic accuracy of immunoglobulin A tissue transglutaminase (IgA tTG) in detecting celiac disease as reported by an authoritative meta-analysis, the 2016 Comparative Effectiveness Review (CER).

Background

Verification bias is introduced to diagnostic accuracy studies when screening test results impact the decision to verify disease status.

Materials and methods

We adjusted the sensitivity and specificity of IgA tTG reported by the 2016 CER with the proportion of IgA tTG positive and negative individuals who are referred for confirmatory small bowel biopsy. We performed a systematic review from January 1, 2007, to July 19, 2017, to determine these referral rates.

Results

The s

SUBMITTER: Hujoel IA 

PROVIDER: S-EPMC7674196 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature