Evidence of early vasogenic edema following minor head impact that can be reduced with a vasopressin V1a receptor antagonist.

ABSTRACT:

Background

Does minor head impact without signs of structural brain damage cause short-term changes in vasogenic edema as measured by an increase apparent diffusion coefficient (ADC) using diffusion weighted imaging? If so, could the increase in vasogenic edema be treated with a vasopressin V1a receptor antagonist? We hypothesized that SRX251, a highly selective V1a antagonist, would reduce vasogenic edema in response to a single minor head impact.

Methods

Lightly anesthetized male rats were subjected to a sham procedure or a single hit to the forehead using a closed skull, momentum exchange model. Animals recovered in five min and were injected with saline vehicle (n = 8) or SRX251 (n = 8) at 15 min post head impact and again 7-8 hrs later. At 2 h, 6 h, and 24 h post injury

SUBMITTER: Kulkarni P 

PROVIDER: S-EPMC7674251 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature