Noninvasive detection of impaired pulmonary artery endothelial function in people living with HIV.

ABSTRACT:

Objective

People living with HIV (PLWH) have an increased risk of pulmonary vascular disease and pulmonary hypertension. Endothelial cell dysfunction is thought to contribute, but human studies have been limited by the invasive nature of conventional measures of pulmonary artery endothelial function (PAEF). We report here a noninvasive MRI approach to measure nitric oxide mediated PAEF by quantifying changes in pulmonary artery area and blood flow during isometric handgrip exercise (IHE), an endothelial nitric oxide dependent stressor. We used this to test the hypothesis that PLWH have impaired PAEF, even before development of pulmonary hypertension.

Design

A prospective cohort study.

Methods

We enrolled 25 HIV-positive viral-suppressed individuals on stable antiretro

SUBMITTER: Goerlich E 

PROVIDER: S-EPMC7674264 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature