Synthesis and cytotoxic analysis of thiolated xylose derivatives decorated on gold nanoparticles.

ABSTRACT: The rapid development of metal nanoparticles capped by an organic monolayer offers the possibility to create a whole new variety of products with novel characteristic, functions and applications. Among these, nanoparticles covered with carbohydrates (glyconanoparticles) constitute a good bio-mimetic model of carbohydrate presentation at the cell surface and are currently centered on many glycobiological and biomedical applications. In this study, a series of novel D-xylose gold nanoparticles (AuNPs) with linkages of alkyl or polyethylene glycol have been synthesized via D-xylosethiols, forming self-assembled monolayers on gold nanoparticles. The nano-gold solution, two carbohydrate derivatives and modified nano-gold solution were tested for cytotoxicity to check the biocompatibility. The M

SUBMITTER: Shiue A 

PROVIDER: S-EPMC7674290 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature